Chemical Chitin Degradation Cosmetics Grade Chitosan Oligosaccharide Raw Materials

Chemical Chitin Degradation Cosmetics Grade Chitosan Oligosaccharide Raw Materials

【Properties Of Cosmetics Grade Chitosan Oligosaccharides】

physical properties of chitosan oligosaccharides

Chitosan oligosaccharides (COS) are linear low molecular weight polymers, which are composed of 2-acetamino-2-deoxy - β - D-glucose and 2-amino-2-deoxy - β - D-glucose residues, connected by β - 1,4-glycosidic bonds in different proportions. The degree of polymerization n is 2-20. Fig. 1 shows the secondary structure of chitosan oligosaccharide. The amino group, hydroxyl group and a small amount of N-acetylamino group in the chitosan oligosaccharide molecule can form intramolecular and intermolecular hydrogen bonds, which makes the chitosan oligosaccharide have greater solubility in water. Wei Xinlin et al. [1] found that the chitosan oligosaccharide has excellent water solubility at pH 1-13, and the solubility in water is 99% respectively. After the chitosan oligosaccharide is dissolved in water, it forms a certain viscosity solution.

chemical properties of chitosan oligosaccharides

The research of chitosan oligosaccharide at home and abroad mainly focuses on the preparation technology of chitosan oligosaccharide, but few on its modification. When chitosan oligosaccharide is modified, the amino and hydroxyl groups in chitosan oligosaccharide molecules participate in the reaction, and can carry out carboxylation, alkylation, acylation, esterification, etherification, metal salt and graft copolymerization.

【Product Specifications】

【Test Case And Dates】

Moisturizing effect of chitosan oligosaccharide

Humectant is an indispensable component in cosmetics. Hyaluronic acid (HA) is a common humectant in cosmetics. Chitosan oligosaccharide and hyaluronic acid have similar structure and properties, which can be used as a substitute for HA in cosmetics.

Hyaluronic acid is a linear polysaccharide structure composed of n-hexylaminoglucose and D-glucuronic acid. Chitosan oligosaccharide is a linear polysaccharide composed of 2-acetamino-2-deoxy - β - D-glucose residue and 2-amino-2-deoxy - β - D-glucose residue linked by β - 1,4-glycosidic bonds in different proportions. The repeating units of both molecular structures are six membered heterocyclic molecules, which are transparent Hyaluronic acid contains active functional groups of carboxyl, carboxyl and amide structure, chitosan oligosaccharide contains active groups of hydroxyl and amino, also contains a small amount of N-acetylamino, under certain conditions can carry out carboxylation reaction and amide condensation reaction; both can form intramolecular and intermolecular hydrogen bonds, have good solubility, form viscoelastic fluid, can be filled in cells and collagen The production process of hyaluronic acid is complex, the raw materials are expensive, and the cost is high. Chitosan oligosaccharide comes from chitin, which is a renewable resource in nature. The preparation process is simple, and the production cost is lower than that of hyaluronic acid. Japan, Korea and other countries have made use of the special properties of chitosan oligosaccharides to develop essence and cleaning products.

antioxidant effect of chitosan oligosaccharide

Researchers at home and abroad have studied the antioxidant activity of chitosan oligosaccharide and its derivatives [5,6]. Zhang Jinghan et al. [7] found that within the concentration range set in the experiment, chitosan oligosaccharide has greater ability to scavenge hydroxyl radicals than chitosan and carboxymethyl chitosan, and the scavenging ability increases with the increase of solution concentration. The scavenging rate of 0.32mg/ml chitosan oligosaccharide is the highest, which is 97.81%, equivalent to 0.64mmol/l anti-oxidation The ability of blood acid to scavenge hydroxyl radical. Dai hung NGO et al. [8] studied the antioxidant activity of galloyl chitosan oligosaccharide by ESR. The results showed that galloyl chitosan oligosaccharide could improve the activity of superoxide dismutase (SOD). Guo fangning et al. [9] showed that the scavenging rate of 2.0mg/ml chitosan oligosaccharide iron complex on superoxide anion radical was 59.84%, and the scavenging rate of DPPH radical was 65.76%.

Chitosan oligosaccharides can absorb ultraviolet rays, eliminate free radicals, activate cells, have good antioxidant, anti-aging, anti fatigue effect, so it can be used in cosmetics to achieve whitening, anti wrinkle, conditioning effect.

antibacterial effect of chitosan oligosaccharide

Chitosan oligosaccharide showed obvious antibacterial activity, and the antibacterial effect increased with the increase of concentration [10,11]. When the concentration of chitosan oligosaccharide was 100 mg / ml, it had a good inhibitory effect on Bacillus subtilis, Escherichia coli and Staphylococcus aureus [12], benhabiles M Syanjiule [13] and others studied the antibacterial activity of chitosan and chitosan oligosaccharide with different molecular weight and deacetylation degree on four gram positive bacteria and seven gram negative bacteria. The study found that chitosan oligosaccharide had good antibacterial effect on the bacteria used in the above experiment, which was better than chitosan.

Chitosan oligosaccharide can be made into cream and other cosmetics, which can reduce the infection of bacteria and fungi, hinder the growth of the original bacteria, inhibit the growth of harmful bacteria on the skin surface, inhibit bacteria growth, and resist skin diseases. It can not only not cause infection to the damaged skin, but also promote the healing of the skin, and eliminate scars and pockmarks. Chitosan oligosaccharides can also be added to toothpaste to inhibit oral bacteria.

2.4 permeability and penetration promoting effects of chitosan oligosaccharides

Chitosan oligosaccharide can form a semi permeable membrane on the skin surface, which has good air permeability, and does not interfere with the excretion of epidermal waste and toxins. It can be used in hair care products to maintain the membrane permeability of the hair surface. It is moist and easy to comb, so that the hair has a natural luster, and can resist static electricity, dust, itching and scurf. The free amino groups of chitosan oligosaccharides can chelate heavy metals and block metal ions, which can be used to develop advanced moisturizing and whitening cosmetics.