Zhongke Runxin (Suzhou) Biotechnology Co., Ltd

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3000Da Anti Inflammatory Chitosan Oligomer In Feed GO2KA1

3000Da Anti Inflammatory Chitosan Oligomer In Feed GO2KA1

  • 3000Da Anti Inflammatory Chitosan Oligomer In Feed GO2KA1
3000Da Anti Inflammatory Chitosan Oligomer In Feed GO2KA1
Product Details:
Place of Origin: China
Brand Name: RunXin
Certification: FDA,ISO9001,ISO22000,FSSC22000
Model Number: RX COS-H85
Payment & Shipping Terms:
Minimum Order Quantity: 1kg
Price: FOB Shanghai USD70-80/kg
Packaging Details: 1kg/bag,10kg/bag,20kg/bag
Delivery Time: 5-8 work days
Payment Terms: L/C,T/T,PAYPAL
Supply Ability: 1000kg/day
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Detailed Product Description
Product: Antiinflammatory Feed Chitosan Oligosaccharide Functions: Antiinflammatory,Resist Inflammation,Anti-inflammatory
Suitable Animals: Chickens, Ducks, Pigs And Other Poultry Granularity: 80 Mesh
Grade: Feed Grade Storage: Dry And Shade
Water Solubility: Water Soluble Shelf Life: 24 Months
Form: Powder CAS No.: 148411-57-8
EINECS No.: 222-311-2 Specification: Deacetylation Degree More Than 90%
Molecular Weight: ≤5000,3000,2000,1000 DA Source: Shrimp Or Snow Crab Shells, Squid Pens, Turtle Shell
Molecular Formula: (C6H11O4N)N(N=2~10) Density: 1.05-1.1
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3000Da Anti inflammatory Chitosan Oligomer


3000Da Chitosan Oligomer


3000Da Anti inflammatory Chito Oligosaccharide

3000Da Anti Inflammatory Chitosan Oligomer In Feed GO2KA1



Product Specifications

Appearance light-yellow powder
Other Name Feed grade chitosan oligosaccharide
Applicable objects Poultry
Product form Powder
Purity 90%
Deacetylation degree >90%
Viscosity (5%) <10cps
Molecular weight Around 700DA
loss on drying <10%
residue on ignition <1%
insoluble <1%
pb <2ppm
As <1ppm
total plate count <1000 cfu/g
mole and yeast <25 cfu/g
E. coli Negative
particle size >80 mesh

Product Introduction


Chitosan oligosaccharide(COS) plays an anti-inflammatory role by binding with related proteins:


COS can combine with IFN - γ to activate macrophages by binding CD14 receptor, toll like receptor 4 (TLR4) and mannose receptor on RAW264.7 cell surface. Feng et al. [14] thought that cos stimulated macrophages to express TNF - α and IL-1 β, and the prerequisite for this effect was cos binding to macrophage surface specific receptor. Mannose (mannose receptor ligand) could inhibit macrophages' Internalization of COS, while LPS (CD14 ligand) and β - glucosamine (CR3 ligand) had no such effect; Other mannose receptors: mannose BSA, fucose BSA and GL CNAC BSA could inhibit the internalization of COS. Therefore, it is considered that the receptor of COS on macrophage membrane is mannose receptor.


GlcNAc monomer inhibited the uptake of COS by macrophages, but GlcN had no such effect, indicating that GlcNAc monomer of COS plays an important role in the recognition of mannose receptor by macrophages. Ym1 is a secreted protein temporarily produced by activated peritoneal exudates during Trichinella spiralis infection in mice. It is a single chain polypeptide with a molecular weight of 43000. Molecular cloning showed that Ym1 had high sequence similarity with chitinase, and had binding specificity for free amino sugars such as glucosamine, galactosamine and glucosamine polysomes. Macrophages activated by inflammation caused by parasite infection or brain injury temporarily overexpress Ym1 [15-16]. These results suggest that Ym1 protein, as an animal type glycobinding protein, plays an important mediating role in the anti-inflammatory effect of COS.


Anti-inflammatory Mechanism

3000Da Anti Inflammatory Chitosan Oligomer In Feed GO2KA1 0

1.Chitosan oligosaccharides exert anti-inflammatory activity by inhibiting nuclear translocation of NF-κ B and expression of inflammatory factors
2.Chitosan oligosaccharides exert anti-inflammatory activity by inhibiting p38 MAPK and ERK1/2 signaling in inflammatory pathway
3.Chitosan oligosaccharides inhibit the expression of IL-8 by blocking p38 and Akt signaling pathway
4.Chitosan oligosaccharides reduce the expression of IL-6 by inhibiting p38 and ERK1/2 signaling pathway

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