Anti-Cancer Ginsenoside Rg3 Ginseng Extract Powder 50% Purity

Anti-Cancer Ginsenoside Rg3 Ginseng Extract Powder 50% Purity

【Biological activity】

Ginsenoside Rg3 is a tetracyclic triterpenoid saponin and a rare active ingredient in ginseng. Its chemical name is 20 (S/R) - damanenediol-3-O - β - D-glucopyranose (1 → 2) - β - D-glucopyranose, with a molecular formula of C ₄₂ H ₇₂ O ₁ I3 and a molecular weight of 784.30.

In 1980, Japanese scholar Isao Kitagawa first isolated and determined the structure of red ginseng.

【Anti-Cancer Ginsenoside Rg3 Ginseng Extract Powder 50% Purity】

【In vitro research Of Anti-Cancer Ginsenoside Rg3 Ginseng Extract Powder 50% Purity】

The inhibitory effect of ginsenoside Rg3 on tumor angiogenesis in nude mice with lung cancer states that ginsenoside Rg3 blocks tumor angiogenesis and inhibits tumor progression by inhibiting the expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF).

In the nude mouse model of lung cancer (subcutaneously inoculated with A549 cells), the Rg3 group (50mg/kg, orally administered once a day for 4 consecutive weeks) showed a 58% reduction in tumor volume and a 62% reduction in tumor weight compared to the model group (p<0.01); The expression of VEGF protein in tumor tissue decreased by 53% (p<0.01), and the microvascular density (MVD) decreased by 49% (p<0.01)

Oncology Reports, 2022, 48 (3): 1-9 states that ginsenoside Rg3 upregulates apoptosis related genes Caspase-3 and Bax, downregulates anti apoptotic gene Bcl-2, and induces tumor cell apoptosis.

A clinical study on gastric cancer patients (preoperative oral administration of Rg3 20mg/time, 3 times a day, for 2 consecutive weeks) showed that Caspase-3 activity in tumor tissue increased by 67% (p<0.05), Bcl-2/Bax ratio decreased by 52% (p<0.05), and postoperative recurrence rate decreased by 28% compared to the control group (followed up for 1 year)