Product:Food Grade Alginate Oligosaccharide Raw Material For Gut Regulation

BRAND:NUGLY MODEL:AOS

Introduction: Fucoidan oligosaccharides, also known as alginate oligosaccharides or alginic acid oligosaccharides, are saturated oligosaccharides with a degree of polymerization ranging from 2 to 10, formed by the alternating linkage of β-D-mannuronic acid sodium and α-L-guluronic acid sodium through 1,4-glycosidic bonds. They exhibit strong water solubility, high stability, and are safe and compliant, making them a popular new ingredient in marine functional foods and health products.

A: Physical indicators

Color and appearance: Greyish-white to light yellow powder

Taste and odor: slightly astringent taste, no obvious irritating odor

Impurities: no visible foreign impurities

B: Physicochemical indicators

Moisture (g/100g): ≤10.0%

Ash content (g/100g): ≤1.0%

PH (1% aqueous solution): 5.5-8.5

Lead (calculated as Pb) mg/kg: ≤2%

Total arsenic (calculated as As) mg/kg: ≤1%

Total mercury (calculated as Hg) mg/kg: ≤0.3%

C: Microbiological indicators:

Total bacterial count: ≤1000 CFU/g

Coliform bacteria: ≤10CFU/g

Mold and yeast: ≤50 CFU/g

Staphylococcus aureus: not detected/25g

Salmonella: Not detected/25g

D: Ingredients:

Sdium alginate, lactic acid, papain, and cellulase

E: Packaging specification:

Aluminum-plastic composite bags lined with high-strength polyethylene plastic film. The specifications are 1.0kg/bag and 10.0kg/bag; the outer packaging is made of paper drums or cartons, with 20kg/drum and 20kg/carton

F: Storage conditions:

Stored in a dry and ventilated warehouse. Keep away from heat sources, strong light, and strong oxidizers. When stored, keep at least 10cm above the ground and 10cm away from the wall. Do not store mixed with toxic or harmful substances

G: Shelf life

Under normal storage conditions, the shelf life is 24 months

Food-Grade Brown Algae Oligosaccharides (AOS): Gut Health Benefits, Mechanisms & Research Data

Core Mechanisms for Gut Health

1. Optimizes Gut Microbiota Balance (Prebiotic Effect)

• Boosts probiotic growth: Significantly increases abundance of Akkermansia muciniphila, Lactobacillus reuteri, Bifidobacterium, and Bacteroides acidifaciens (up to 2–5 fold in animal studies).
• Suppresses harmful bacteria: Reduces E. coli, Salmonella, and Helicobacter by 40–60%, lowering infection risk.
• Why it works: AOS’s unique molecular structure (mannuronic/guluronic acid oligomers) is fermentable only by beneficial gut microbes, avoiding pathogen utilization.

2. Enhances Intestinal Barrier Function

• Upregulates tight junction proteins: Increases expression of ZO-1, occludin, and claudin by 30–50%, sealing gaps between intestinal epithelial cells.
• Thickens mucus layer: Stimulates mucin secretion (+25–40%), protecting the gut lining from irritants and pathogens.
• Supports epithelial repair: Fuels intestinal cells via short-chain fatty acids (SCFAs) (acetate, propionate, butyrate) produced during AOS fermentation.

3. Reduces Gut Inflammation & Oxidative Stress

• Inhibits pro-inflammatory signals: Blocks TLR4/MAPK/NF-κB pathways, reducing pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) by 35–60%.
• Boosts antioxidant capacity: Upregulates superoxide dismutase (SOD) and glutathione (GSH), lowering oxidative damage (MDA ↓40%).
• Relieves inflammatory bowel disease (IBD): In DSS-induced colitis models, AOS reduces colon shortening and tissue damage, with 50–70% lower disease activity index (DAI).

4. Improves Bowel Regularity & Nutrient Absorption

• Promotes gut motility: Fermentation of AOS produces SCFAs that stimulate intestinal peristalsis, relieving constipation in 60%+ of test subjects.
• Enhances mineral absorption: Improves calcium, magnesium, and iron uptake by 15–25% via gut pH modulation and barrier enhancement.

Validated Research Data (Animal & In Vitro Studies)

Key Advantages for Commercial Use

• Food-grade safety: GRAS-compliant, non-toxic, no side effects (LD50 >5000 mg/kg in animal tests).
• High stability: Resists gastric acid and heat (stable at pH 2–8, up to 80°C), ideal for various formulations.
• Wide compatibility: Works with probiotics, fiber, and vitamins—synergizes with Lactobacillus for enhanced gut benefits.

Ideal Applications

• Gut health supplements (capsules, powders, liquids)
• Functional foods (yogurt, cereals, baked goods)
• Pediatric and senior gut support formulations
• Post-antibiotic gut recovery products