High purity Ginsenoside Compound K raw material for metabolic health
1. Product Overview
Ginsenoside Compound K (CK, IH901) is a rare, deglycosylated protopanaxadiol-type ginsenoside. It is the final active metabolite of major ginsenosides Rb1, Rb2 and Rc after intestinal biotransformation. With low molecular weight, high lipophilicity and superior oral bioavailability, CK exhibits outstanding metabolic regulatory activity. Modern preclinical studies prove that CK modulates adipogenesis, lipid metabolism and energy balance, serving as a premium natural ingredient for healthy weight management and metabolic wellness formulas.
2. Physicochemical Properties
CAS No.: 39262-14-1
Chemical Formula: C₃₆H₆₂O₈
Molecular Weight: 622.88 g/mol
Appearance: White to off-white crystalline powder
Solubility: Soluble in ethanol, methanol and DMSO; slightly soluble in water
Stability: Stable under cool, dry and sealed storage; hygroscopic, avoid strong light
Production Technology: Microbial enzymatic bioconversion, high purity, low impurity
Available Specifications: HPLC 98%, 95%, 80%
Core Physical Advantage: Small molecular structure and moderate lipophilicity ensure high intestinal absorption efficiency, far exceeding traditional macromolecular ginsenosides, supporting systematic metabolic regulation.
3. Mechanism of Action for Weight & Metabolic Management
Excessive fat accumulation and metabolic disorder are mainly caused by abnormal adipocyte differentiation, blocked lipid catabolism and unbalanced energy metabolism. CK regulates lipid homeostasis through multi-target molecular pathways, effectively supporting healthy body composition and metabolic balance.
3.1 Inhibit Adipocyte Differentiation & Fat Formation
CK significantly downregulates the expression of key adipogenic transcription factors PPARγ and C/EBPα, blocks the differentiation of preadipocytes into mature fat cells, and reduces excessive lipid droplet formation and fat deposition in adipose tissue.
3.2 Activate AMPK Lipid Metabolism Pathway
CK activates AMPK signaling, inhibits ACC activity, accelerates fatty acid β-oxidation, reduces triglyceride accumulation, and enhances endogenous lipid catabolism to maintain lipid balance.
3.3 Regulate Glucocorticoid Receptor (GR) & Lipophagy
As a selective GR agonist, CK triggers lipophagy, promotes the degradation of intracellular lipid droplets, and improves abnormal lipid metabolism induced by metabolic stress, limiting excessive fat proliferation.
3.4 Improve Insulin Sensitivity & Glucose-Lipid Homeostasis
CK optimizes GLP-1 secretion and modulates gut microbiota-bile acid metabolism, improves insulin resistance, and avoids fat accumulation caused by long-term glucose metabolism disorder.
3.5 Modulate Gut Microbiota for Metabolic Wellness
CK reshapes intestinal flora structure, enriches beneficial bacteria related to lipid metabolism, optimizes enterohepatic circulation of bile acids, and fundamentally improves metabolic disorder symptoms.
4. Preclinical Research Data
All data are sourced from published 3T3-L1 adipocyte models and high-fat diet (HFD) rodent studies, for formulation R&D reference only.
4.1 Cellular Level Data
In differentiated 3T3-L1 adipocytes, CK treatment dose-dependently reduced intracellular triglyceride content, downregulated PPARγ and FAS protein expression, and effectively inhibited adipocyte hypertrophy and lipid overaccumulation.
4.2 In Vivo Animal Model Data
In HFD-induced metabolic disorder animal models, CK intervention significantly reduced excessive body weight gain, decreased visceral fat ratio, and improved serum lipid indexes (TC, TG, LDL), showing obvious lipid-regulating effects.
CK treatment effectively relieved hepatic lipid deposition, repaired metabolic liver damage caused by high-fat diet, and maintained stable systemic metabolic level.
4.3 Mechanism Verification Data
CK upregulated AMPK phosphorylation level and activated lipophagy pathway; significantly improved intestinal flora dysbiosis, increased the abundance of metabolic beneficial bacteria, and optimized body energy metabolism efficiency.
5. Core Applications
- Functional raw materials for healthy weight management supplements
- Natural lipid metabolism regulation functional ingredients
- Formulation raw materials for improving body composition
- Metabolic balance & insulin sensitivity support products
- Gut metabolism conditioning compound formula ingredients
6. Product Advantages
- High bioavailability: Metabolite active form, superior absorption than primitive ginsenosides
- Multi-target regulation: Integrates fat inhibition, lipid catabolism and gut metabolism optimization
- Mature research basis: Complete published preclinical data, convenient for product promotion and literature support
- High safety: Natural ginseng-derived ingredient, low toxicity, suitable for long-term oral formula
- Stable quality: Enzymatic conversion process, stable batch difference, complete COA/HPLC/MS qualification documents.
Weight↓12.7% sWAT/vWAT ↓50%
Recommended dosage:CK 100-150mg/d
