Organic Ginseng Root 90% Ginsenoside CK Compound K For Anti-Cancer Functuonal Raw Material

Organic Ginseng Root 90% Ginsenoside CK Compound K For Anti-Cancer Functuonal Raw Material

【Biological activity】

Ginsenoside C-K is a bacterial metabolite of Ginsenoside Rb1.

Ginsenoside C-K exerts anti-inflammatory effects by inhibiting inducible nitric oxide synthase (iNOS) and COX-2.

In human liver microsomes, Ginsenoside C-K inhibits CYP2C9 and CYP2A6 activity with IC50 values of 32.0 ± 3.6 μ M and 63.6 ± 4.2 μ M, respectively.

【Organic Ginseng Root 90% Ginsenoside CK Compound K For Anti-Cancer Functuonal Raw Material 】

【In vitro research Of Organic Ginseng Root 90% Ginsenoside CK Compound K For Anti-Cancer Functuonal Raw Material】

The study "Effects of Ginsenoside CK on Hepatocellular Carcinoma Cell Proliferation and PI3K/Akt Pathway" states that Ginsenoside CK blocks the PI3K/Akt/mTOR signaling pathway, inhibiting tumor cell proliferation and protein synthesis.

In the nude mouse model of breast cancer (inoculated with MCF-7 cells), the tumor volume in the CK (30mg/kg, intraperitoneal injection, three times a week for four consecutive weeks) group was 49% smaller than that in the model group (p<0.01), and the apoptosis index (TUNEL positive cell rate) was 3.2 times higher (p<0.01)

The International Journal of Biological Macromolecules, 2022, 217: 562-571. states that ginsenoside CK enhances chemotherapy drug sensitivity, and when combined with cisplatin and paclitaxel, it can reduce tumor cell resistance, promote DNA damage and apoptosis.

Liver cancer HepG2 cell experiments showed that after 48 hours of treatment with CK (50 μ mol/L), the cell proliferation inhibition rate reached 52% (p<0.01), and the phosphorylation levels of PI3K and Akt proteins decreased by 47% and 53%, respectively (p<0.01); After combination with cisplatin (2 μ g/mL), the inhibition rate increased to 78% (35% higher than cisplatin alone, p<0.01)