Bulk chitosan oligosaccharide powder for immune enhancement supplement raw material

Bulk chitosan oligosaccharide powder for immune enhancement supplement raw material

1. Physicochemical Properties

1. Appearance: White to faint yellow fine powder, odorless or faint natural seafood scent
2. Molecular Weight & DP: Average MW 320–1610 Da, Degree of Polymerization (DP)=2–10 (core immune-active fraction), DP＜10 ensures high bioavailability
3. Solubility: 100% water-soluble under neutral/weak acidic aqueous solution (pH 5.0–7.0); insoluble in ethanol, acetone and other organic solvents, distinct from high-molecular chitosan (hardly soluble in water)
4. Deacetylation Degree ≥92%: Free cationic amino groups on molecular chain, the core structural basis for immune binding with cell receptors
5. Quality Index (Food Grade): COS purity ≥90% (dry base); Moisture ≤10%; Ash ≤1.0%; Heat stable below 120℃, sealed dry storage required due to mild hygroscopicity
6. Absorption Rate: Up to 99.8% intestinal absorption, directly absorbed via small intestinal epithelial transporter Slc9a1 without gastrointestinal digestion obstruction

2. Immunomodulatory Mechanism & Verified Research Data

2.1 Direct Immune Cell Activation (In Vitro RAW264.7 Macrophage Test)

• At dosage 1–2 mg/mL COS treatment for 24 h, RAW264.7 macrophage NO secretion rises 128% vs blank control group; mRNA expression of immune cytokines TNF-α, IL-6, IFN-γ upregulates by 1.9~2.7 folds, significantly boosting innate immune phagocytosis
• COS promotes NK cell proliferation activity by 42% in peripheral blood test, strengthens body’s anti-virus & anti-abnormal cell immunity

2.2 Intestinal Mucosal Immunity Improvement (In Vivo Mouse Trial, Published on International Immunopharmacology)

1. Oral COS daily supplement elevates small intestinal SIgA secretion by 61%, SIgA is core mucosal immune antibody blocking pathogen invasion of digestive tract;
2. Modulates gut microbiota: Enrich Bifidobacterium & Lactobacillus abundance by 55%+, elevates short-chain fatty acid (SCFA) production, optimizes gut barrier integrity to cut inflammatory leakage; ranked top among mainstream prebiotics (FOS/GOS/AOS) for gut immune regulation efficiency.

2.3 Immune Balance & Anti-allergic Regulation Data

• Restrains mast cell degranulation by 53%, reduces over-released allergic inflammatory mediators (histamine); balances Th1/Th2 immune ratio to relieve seasonal allergic immune overreaction
• For cyclophosphamide-induced immunosuppressive mice model: Continuous 14-day COS oral administration restores spleen & thymus immune organ index by 38%, recovers peripheral leukocyte quantity close to normal level, widely applied as adjuvant supplement for post-chemotherapy immune recovery

2.4 Immunoadjuvant Value

3. Product Summary 

1. Bulk Raw Material (B2B): Ideal supplement raw material for immune-boosting capsules, powder sachets, functional drink, pet & aquafeed immune additives, compliant with EU/US food supplement ingredient standards;
2. Finished Supplement Raw Material (B2C): Core functional component for daily immunity care, gut health & seasonal allergy relief dietary supplements.
    
   With stable batch specification and complete COA, SDS & third-party test reports, our immune-focused COS is a premium niche ingredient in global immune health track.