Bulk water soluble chitooligosaccharide prebiotic raw material for gut health supplement

Chitosan oligosaccharide (COS) for Intestinal Regulation | English Product Description

1. Physicochemical Properties

1. Appearance: Off-white to pale yellow fine powder, odorless with faint natural marine scent, free of insoluble impurities.
2. Molecular Specification: Average molecular weight 300–1600 Da, Degree of Polymerization DP=2–10 (core gut-active fraction); Deacetylation Degree ≥92%, abundant free cationic amino groups as core functional structure for gut binding.
3. Solubility: Fully water-soluble at pH 4.5–7.2 (physiological intestinal environment), completely different from high-molecular chitosan which is barely soluble in water; insoluble in ethanol and organic solvent.
4. Quality Index: COS purity ≥90% (dry basis), moisture ≤9.0%, total ash ≤1.0%; stable below 115℃, slight hygroscopicity requiring sealed cool dry storage.
5. Digestive characteristic: Cannot be degraded by human upper gastrointestinal digestive enzymes, intactly passes stomach & small intestine to colon to exert prebiotic effects; partial small-molecule fraction directly absorbed via intestinal epithelial carrier protein.

2. Intestinal Regulation & Mucosal Immune Mechanism with Verified Experimental Data

2.1 Regulate Intestinal Microbiota (Prebiotic Core Effect, Human & Animal Clinical Data)

• Human oral trial (1.5g daily intake for 28 days): Fecal Bifidobacterium & Lactobacillus concentration rises by 1.7–1.9 log CFU/g; harmful E.coli, Klebsiella abundance drops 52%~58% vs blank control.
• Fermentation boosts short-chain fatty acids (SCFAs, butyrate & acetate) production by 43%, SCFA fuels colonocyte metabolism and maintains colon microecology balance.

2.2 Repair Intestinal Epithelial Barrier & Improve Leaky Gut

• In-vivo colitis mouse test: Serum DAO (intestinal permeability marker) decreases by 71% after continuous 14-day COS supplementation; intestinal goblet cell quantity increases 39% to thicken intestinal mucus barrier.

2.3 Boost Intestinal Mucosal Immunity via SIgA Elevation

• Oral administration data: Small intestinal SIgA secretion improves by 59% after 30-day daily supplementation; lowers local intestinal inflammatory factors IL-6, TNF-α concentration by 45%–51% via inhibiting NF-κB inflammatory pathway, easing mild enteritis and recurrent bloating.

2.4 Relieve Digestive Discomfort

3. Product Summary

Application Scenarios

1. B2B Bulk Raw Material: Core prebiotic ingredient for gut-health powder sachets, probiotic compound capsules, functional beverage, pet intestinal care supplement and aquafeed additives; complete COA, SDS and third-party test documents for global wholesale procurement.
2. B2C Finished Supplement Formula: Premium natural marine prebiotic for daily gut care, post-antibiotic gut flora recovery, irritable bowel syndrome auxiliary nutrition for adults and elderly users.
    
   As niche non-plant derived prebiotic ingredient superior to conventional FOS/GOS on gut immune regulation, COS occupies high-growth gut health track for global dietary supplement manufacturers.
3.