Chitosan Oligosaccharide

Mechanism of Action for Gut Barrier Repair & Intestinal Health

1. Strengthen epithelial tight junctions: Upregulate expression of tight junction proteins including ZO‑1, occludin and claudin, seal the intercellular gaps, reduce intestinal permeability and mitigate leaky gut, preventing bacterial and endotoxin translocation.
2. Protect intestinal mucus layer: Stimulate MUC2 mucin secretion, maintain the protective mucosal layer covering intestinal epithelium and reduce epithelial cell injury.
3. Balance gut microbiota (prebiotic effect): Promote proliferation of beneficial bacteria such as Lactobacillus and Bifidobacterium, inhibit colonization of pathogenic microbes, and restore microbial balance.
4. Relieve intestinal mucosal inflammation & oxidative stress: Suppress overactivation of NF‑κB pathway, cut down pro‑inflammatory cytokines (TNF‑α, IL‑6, IL‑1β); activate antioxidant signaling to reduce oxidative damage to intestinal tissue.
5. Accelerate epithelial regeneration: Support renewal and repair of intestinal epithelial cells to recover mucosal integrity after damage.

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Application Research Data

• In vitro cell model: Chitosan oligosaccharide increases tight junction protein expression in intestinal epithelial cells, significantly reduces epithelial permeability triggered by inflammatory and oxidative stimuli.
• DSS-induced colitis animal model: Oral COS supplementation restores colonic mucosal structure, elevates ZO‑1, occludin and MUC2 expression, lowers serum LPS and DAO levels, and alleviates mucosal injury and inflammatory infiltrationPMC.
• LPS-challenged animal trial: COS inhibits intestinal inflammation and oxidative stress, reverses the down‑regulation of tight junction proteins induced by LPS, and reduces endotoxin translocation from gut lumen into blood circulationSemantic S....
• Feed application data: In livestock studies, dietary chitosan oligosaccharide improves jejunal tight junction protein expression, reduces diarrhea incidence, enhances nutrient digestibility and maintains intestinal health under stress conditionsPMC.
• Nutraceutical application: In human gut health formulations, continuous intake helps reduce low-grade intestinal inflammation, stabilizes gut permeability and supports long-term intestinal homeostasis.

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Bullet-Point Compact Version (Product Card / PDF Datasheet)

Chitosan Oligosaccharide