Chitosan oligosaccharide for liver protection and hepatoprotective support with 100% water solubility

Chitosan Oligosaccharide

Mechanism of Action for Acute & Alcoholic Liver Injury

1. Activate Nrf2 antioxidant pathway: Trigger Keap‑1/Nrf2 signaling, upregulate downstream antioxidant proteins HO‑1, NQO1, SOD and GSH‑Px; scavenge excess ROS, reduce lipid peroxidation, relieve acute oxidative shock of hepatocytesPubMed.
2. Optimize alcohol metabolic flux: Upregulate ADH and ALDH expression to accelerate acetaldehyde clearance; suppress overexpression of CYP2E1, cut down toxic metabolite generation during ethanol metabolismWiley Onli....
3. Block inflammatory cascades: Inhibit over‑activation of NF‑κB and MAPK (p38, JNK, ERK) pathways, lower pro‑inflammatory cytokines TNF‑α, IL‑6, IL‑1β, reduce inflammatory infiltration in liver tissue万方数据.
4. Stabilize hepatocyte membrane & suppress apoptosis: Reduce hepatocyte necrosis and apoptosis induced by toxins or ethanol, limit leakage of liver transaminases into blood circulation.
5. Gut‑liver axis protection: Reinforce intestinal tight junctions, reduce LPS translocation and gut‑derived endotoxemia, which is a major driver of secondary hepatic injury after alcohol or toxic challenge.

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Application Research Data

• In vitro hepatocyte model (L02): Chitosan oligosaccharide dose‑dependently reduced ethanol‑triggered ALT/AST release, lowered intracellular ROS accumulation and restored GSH depletion in injured hepatocytesPMC.
• CCl₄-induced acute liver injury mouse model: Pre‑administration of COS markedly decreased serum ALT and AST, suppressed hepatic elevation and recovered SOD/GSH‑Px activity. Liver histology showed alleviated hepatocyte swelling, focal necrosis and inflammatory infiltrationPMC.
• Acute ethanol binge model: COS intervention reduced liver index, serum ALT, AST and TG levels; improved hepatic steatosis and inflammatory lesions after acute alcohol exposure (p<0.05).
• Mechanism verification: COS downregulated CYP2E1 protein, activated Nrf2, and inhibited phosphorylation of MAPK and NF‑κB, reversing ethanol‑mediated oxidative and inflammatory hepatic damagePubMed.
• End‑use performance: Suitable for hangover support and liver care dietary supplements for occasional alcohol exposure; in animal nutrition, it protects liver against mycotoxin, chemical and alcohol‑related acute toxic stress.

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